Median infective dose of Treponema pallidum determined in a highly susceptible guinea pig strain.
نویسندگان
چکیده
The median infective dose of Treponema pallidum subsp. pallidum and the production of immunity to reinfection in C4D guinea pigs have been determined with 10(1) to 10(6) organisms per infective dose. The mean infective dose is 10(2) organisms, and immunity--in those animals that demonstrated lesions--developed after 4.5 months postinfection.
منابع مشابه
Experimental syphilis: guinea pig model.
Outbred Hartley male guinea pigs (300-400 g) were infected intradermally with various concentrations of Treponema pallidum Nichols strain in the pubic region. The median lethal dose (ID50) was approximately 10(5). The animals produced lesions visible by darkfield microscopy, treponemal antibodies (IgG only), and histopathological changes in the lymphoid organs. Though less susceptible to T pall...
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عنوان ژورنال:
- Infection and immunity
دوره 59 1 شماره
صفحات -
تاریخ انتشار 1991